ClpP inhibitor M21( —— )

Catalog No. M10535 CAS No. 1151944-58-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ClpP inhibitor M21
Note

Research use only, not for human use.
Brief Description

ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM.
Description

ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay; alters α-toxin expression in a ClpP-dependent manner and attenuate S. aureus virulence via ClpP inhibition; blocks the pathogenicity of infection in animal models.
In Vitro

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In Vivo

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Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1151944-58-9
Formula Weight

385.452
Molecular Formula

C19H15NO4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC=C(C=C1)COC2=CC=C(C=C2)C=C3C(=O)N(C(=S)S3)CC(=O)O
Chemical Name

(Z)-2-(5-(4-(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

1. Gao P, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201720520.

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